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Fitness and Atrial Fibrillation

What is the relationship between cardiorespiratory fitness (CRF) and the risk of atrial fibrillation (AF)? The FIT project study group consisted of 64,561 adults (mean age, 55 years; 46% female; 64% whites) who underwent clinically indicated exercise treadmill testing (ETT). There were 4,616 new cases of AF over a median follow-up period of 5.4 years. […]

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Chemotherapy-induced cardiotoxicity: Who Will Get Chemotherapy-Induced Cardiotoxicity?

  Many of the chemotherapeutic agents in use today can have associated cardiovascular side effects, the most common of which are cardiomyopathy and heart failure (HF). Amongst the various medications, the anthracycline class of drugs (e.g., doxorubicin and epirubicin) and the human epidermal growth factor receptor type 2 (HER 2) monoclonal antibody, trastuzumab, have been […]

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Myocardial Strain Imaging by Echocardiography for the Early Detection of Chemotherapy-induced Cardiotoxicity

The mortality rate among patients with cancer has decreased over the past 20 to 30 years. However, cardiac toxicity (cardiotoxicity) from cancer therapy has become a leading cause of morbidity and mortality in survivors. In patients who develop heart failure (HF) from cancer therapy, the mortality rate is as high as 60% by 2 years. […]

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In non–ST elevation acute coronary syndrome with and without percutaneous coronary intervention, pretreatment with thienopyridines did not reduce mortality and was associated with increased risk for major bleeding

To investigate the effect of pretreatment with P2Y12 receptor inhibitors compared with no pretreatment on efficacy and safety of treatment of non-ST elevation acute coronary syndrome (ACS). The authors of this paper report the results of a pooled analysis of randomized and observational studies of pretreatment with thienopyridines (clopidogrel or prasugrel) vs no pretreatment in […]

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Antibiotic associated with increased risk for sudden death in patients taking ACE inhibitors or ARBs

  Trimethoprim/sulfamethoxazole (or co-trimoxazole) was associated with an increased risk of sudden death in older patients receiving angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs), a study found (published online Oct. 30, 2014 by BMJ). Researchers conducted a population-based, nested, case-control study in Ontario, Canada, from April 1994 to January 2012 among patients age 66 […]

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2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes (NSTE-ACS): 10 Points to Remember

The new guideline emphasizes the pathophysiologic continuum of unstable angina and NSTEMI and their frequently indistinguishable clinical presentations. In terms of treatment, another notable element of the new guideline, is the recognition that while an early invasive strategy for patients with NSTE-ACS with significant coronary artery disease is generally accepted, low-risk patients can substantially benefit […]

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Colchicine for Recurrent Pericarditis

In a new trial (Lancet March 30, 2014), colchicine, was found to be safe and beneficial adjunct to nonsteroidal anti-inflammatory drugs, even in patients with multiple recurrences.  Previous trials have demonstrated the efficacy and safety of colchicine as an adjunct to conventional treatment in patients with acute pericarditis or first recurrences. To assess whether colchicine’s […]

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Effect of ACE Inhibitors and ARBs on Cardiovascular Outcomes in Diabetes

A recent meta-analysis, published in JAMA Intern Med on March 31, 2014, analyzed the effect of ACE inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) on all-cause mortality, cardiovascular (CV) deaths, and major CV events in patients with diabetes mellitus (DM). The authors of this study included randomized clinical trials reporting the effects of ACEI […]

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FDA: Does Not Recommend Using Aspirin for Primary Prevention of Heart Attack or Stroke

Aspirin should not be used to prevent a first heart attack or stroke in patients with no history of cardiovascular disease, according to the U.S. Food and Drug Administration (FDA). In a statement released on May 5, 2014, the FDA said that its review of available data does not support the use of aspirin for […]

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Antibiotics Linked to Increased Risks for Arrhythmia and Mortality

Azithromycin use has been associated with increased risk of death among patients at high baseline risk, but not for younger and middle-aged adults. The Food and Drug Administration issued a public warning on azithromycin, including a statement that the risks were similar for levofloxacin. Researchers conducted a retrospective cohort study among US veterans to test […]

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